About Us

It’s Time for a New Direction in Treating Alzheimer’s and Parkinson’s Disease

WE ARE DEDICATED TO REVERSING THE PROGRESSION OF DEBILITATING NEURODEGENERATIVE DISEASES.
OUR DRUGS ATTACK NEURODEGENERATION BY RESTORING AXONAL TRANSPORT, THE INFORMATION HIGHWAY OF THE NERVE CELL, WHICH HAS BEEN SHOWN TO BE THE CAUSE OF NERVE CELL DEGENERATION AND ULTIMATELY DEATH.

Our collaboration with Professor Mobley’s laboratory in Down Syndrome (DS) mice has shown that our drug lowers the levels of neurotoxic proteins, normalizes axonal transport in the brain of these mice and by doing so restores memory and learning. Mobley’s data proves that DS is a good model for Alzheimer’s disease (AD) and developing ANVS-401 for dementia and AD in DS patients allows us to obtain human data in an orphan subpopulation much faster than in the regular AD population.

We have shown in a number of animal studies that lowering neurotoxic proteins restores homeostasis and fully recovers the affected function: in AD mice ANVS-401 restores brain function, memory and learning; in Parkinson’s mice the drug restores gut motility and in Traumatic Brain Injury rats the drug protects nerve cells, lowers inflammation and restores memory and learning.

In humans, in spinal fluid of mildly cognitive impaired patients ANVS-401 normalizes levels of neurotoxic proteins and lowers inflammation.

Management Team

Maria L. Maccecchini, PhD

Maria L. Maccecchini, PhD

Founder, President & CEO

Jeffrey Cummings, MD

Jeffrey Cummings, MD

SAB Member

Jeffrey McGroarty

Jeffrey McGroarty

Chief Financial Officer

Board of Directors

Michael Hoffman

Michael Hoffman

Chairman of the Board

Maria L. Maccecchini, PhD

Maria L. Maccecchini, PhD

Founder, President & CEO

Claudine E. Bruck, PhD

Claudine E. Bruck, PhD

Board Member

Mark White

Mark White

Board Member

Robert M. Whelan, Jr.

Robert M. Whelan, Jr.

Board Member

Scientific Advisory Board

Sidney Strickland, PhD

Sidney Strickland, PhD

SAB Chairman

Peter Davies, PhD

Peter Davies, PhD

Director of the Litwin-Zucker Research Center

William Mobley, PhD

William Mobley, PhD

Distinguished Professor, UC San Diego

Jeffrey Cummings, MD

Jeffrey Cummings, MD

SAB Member

Gregory Petsko, PhD

Gregory Petsko, PhD

SAB Member

Rudolph E. Tanzi, PhD

Rudolph E. Tanzi, PhD

SAB Member